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Conduct independent research activities under the guidance of a faculty mentor in preparation for afull-time academic or research career. Work Performed Seeking a highly motivated postdoctoral research associate to investigate genetic and epigenetic causes of late-onset Alzheimers disease. The successful applicant will have a strong and productive scientific record, be highly collaborative, inquisitive, diligent, and have previous experience in one or more of the relevant fields: human genetics, neurobiology, functional genomics, molecular biology, RNA biology, and bioinformatics.
The ideal candidate should be less than two years out from their Ph.D. and should demonstrate excellent verbal and written communication skills. The lab investigates genetic and molecular mechanisms controlling neurodegeneration and neuronal aging and contributing to neurodegenerative pathologies, and age-related brain diseases. To tackle these questions, we employ genomic technologies, single-cell analyses of human brain tissues, iPSC-derived models, humanized mouse, bioinformatics tools, and genomic/epigenomic/transcriptomic datasets. The lab has ongoing collaborations with labs at Duke as well as with other national and international investigators. The primary goal for this position will be to investigate the underpinnings of how Alzheimers GWAS discoveries translate to disease causal mechanisms. The postdoctoral associate will implement cutting-edge technologies in functional genomics, molecular profiling, single-cell analyses, and model systems primarily iPSC gene-edited derived neurons. Additionally, the postdoctoral associate will have the opportunity to pursue complementary projects in the lab at the intersection of molecular genetics and neurodegenerative diseases in aging.
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